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Anoxia is the condition of lacking free oxygen. An environment (usually a body of water) exhibiting anoxia is said to be anoxic.

Anoxia is biologically important because most higher life requires free oxygen for its respiration (aerobic respiration). Respiration without oxygen is called anaerobic and is mostly found among , some of which cannot even live in the presence of free oxygen.

During the and the entire biosphere was anoxic and stayed that way till plants became dominant. When the Earth's atmosphere came to include large amounts of free oxygen that was called the and lead to a of anaerobic organisms.

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