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In the geologic timescale, the Asselian is the earliest geochronologic age or lowermost chronostratigraphic stage of the Permian. It is a subdivision of the Cisuralian epoch or series. The Asselian lasted between 299.0 ± 0.8 and 294.6 ± 0.8 million years ago (Ma). It was preceded by the Gzhelian (the latest or uppermost subdivision in the Carboniferous) and followed by the Sakmarian.
Life in the Asselian times had not changed much from the latest Carboniferous. There were still swampy forests of huge trees, and a fauna dominated mostly by stem tetrapods with only a few medium-sized reptiles.
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According to the National Institutes of Health, approximately 5 percent of 40-year-old men and between 15 and 25 percent of 65-year-old men experience ED on a long-term basis.
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The classic test to find out whether the problem is psychological or physical is to measure "nocturnal tumescence." This involves wrapping a strip of paper or tape around the flaccid penis at night. If the strip is broken in the morning, an erection likely occurred during sleep and impotence is most likely a psychological one.
Four experiments were conducted. Experiment one examined the effect of L-NMMA on NMDA mediated behavioral responses in normal rats; experiment two measured behavioral responses to NMDA or sodium nitroprusside (SNP), an NO donor in both control and diabetic rats; the third experiment observed the effect of diabetes on nNOS protein in the PVN; the fourth experiment measured NMDA mediated behavioral responses in diabetic rats after restoring the nNOS protein in the PVN using viral gene transfer.
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Treatment depends on the cause. Testosterone supplements may be used for cases due to hormonal deficiency. However, the cause is more usually lack of adequate penile blood supply as a result of damage to inner walls of blood vessels. This damage is more frequent in older men, and often associated with disease, in particular diabetes.
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