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Continental drift is a theory advanced particularly by Alfred Wegener that tried to explain the fact that coastlines of land masses at opposite ends of for example the Atlantic ocean match each other in shape. The coastlines of Greenland and Norway are a good example
This remarkable fact had undoubtedly been noticed by generations of school children as long as reasonable maps had been available, but an explanation was lacking. Actually comparison is not limited to the shape of the coast line but also stretches to the geological features at either side of it. The opposite can be said about mountain ranges that seemed to be sutures between two disparate land masses.
Wegener proposed that these remarkable observations were the result of the drifting apart of continents that has once been connected or -in the case of mountain ranges- of the collision of two land masses. Unfortunately for his theory he could not come up with a credible mechanism for the movement of whole land masses over distances of thousands of mile. The geological community largely derided his theory. In an attempt to actually measure the movement of Greenland away from Northern Europe Wegener lost his life.
After his death there were few scientist that even dared to continue his line of thinking. A notable exception was the South African Du Toit who investigated the continuity of the layers of his homeland with those of the opposite landmass South America. Even though his work showed even more striking resemblances, main stream geology would not hear of his findings and until the early 1970s it was not unusual for European students of Geology to be taught that continental drift was pseudoscience.
Then Wegener was vindicated. Methods to study the bottom of the oceans became available and these showed very clearly that the crust of the Atlantic ocean was youngest at the mid-oceanic rift. Sideways from there new oceanic crust is constantly being produced, widening the Atlantic ocean and pushing Norway and Greenland, Argentina and South Africa farther apart. This time Geophysics did come up with a credible mechanism involving convection currents in the Earth's mantle. The new theory, successor to continental drift, is known as .
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The physical examination can reveal clues for physical causes of erectile dysfunction. For example, if the penis does not respond as expected to touching, a problem in the nervous system may be the cause. Small testicles, lack of facial hair and enlarged breasts can point to hormonal problems such as hypogonadism with low testosterone levels. A reduced flow of blood as a result of atherosclerosis can sometimes be diagnosed by finding diminished arterial pulses in the legs or listening with a stethoscope for bruits (the sound of blood flowing through narrowed arteries). Unusual characteristics of the penis itself could suggest the root of the erectile dysfunction, for example, bending of the penis during erection could be the result of Peyronie's disease.
A. Patients typically achieve an erection within 20 minutes. The erection can last between 30 and 90 minutes, becoming more rigid with sexual stimulation. However, the erection does not always disappear immediately after ejaculation. If too much of the drug has been administered, priapism - an unwanted, prolonged erection that lasts for longer than three or four hours - can develop. This painful and dangerous medical condition is named for Priapus, the Greek god of procreation. It can lead to the destruction of erectile tissue if left untreated. Thankfully, this serious condition can be reversed by injecting an adrenaline-like drug into the penis.
Figure 6. In vivo PDE5 inhibition down-regulates tumor-associated MDSC suppressive pathways. BALB/c mice were challenged with 0.5 x 106 C26GM cells and treated with sildenafil starting on day 0 or left untreated for 9 d. CD11b+ cells were obtained from the tumors and used to measure (A) intracellular cGMP and (B) IL-4R surface expression by flow cytometry. (C) Western blot analysis was performed for NOS2, ARG1, and ?-actin expression on purified tumor-associated CD11b+ cells. (D) NO production was determined as the concentration of NO3-NO2 in the supernatant, and arginase activity was determined on cell lysates and normalized for the number of cells. (E) BALB/c mice were challenged with C26GM, treated with sildenafil or the anti–Gr-1 depleting antibody, both treatments, or left untreated. Best fit of the data was obtained by four-parameter sigmoid curves. ANOVA p-values (PA) are reported. Error bar values are shown. MFI, multiplicity of infection.
The use of oral therapy has long been preferred over invasive procedures such as injection therapy for erectile dysfunction. We review the pharmacology, efficacy and side effects of the newest agents available for oral therapy: the PDE-5 inhibitors sildenafil, vardenafil and tadalafil.
TUESDAY, April 14 (HealthDay News) -- The erectile dysfunction drugs Cialis (tadalafil) and Viagra (sildenafil) didn't appear to damage vision in men who took the medications daily for six months, according to a drug company study.
In one Hong Kong-based study involving 2,306 men with type-2 diabetes, slightly more than one fourth of the subjects had erectile dysfunction at the start of the study, and none of the participants had any signs or history of heart disease, stroke or vascular disease. After four years, 123 of these men either experienced a heart attack, died from heart disease, developed chest pain caused by clogged arteries, or needed bypass surgery or a catheter procedure to restore blood flow to the heart. Men who had erectile dysfunction at the beginning of the study were much more likely to experience one of these coronary heart disease (CHD) events. A statistical analysis revealed that out of every 1,000 diabetic men with erectile dysfunction, 19.7 could be expected to experience a CHD event each year, as compared to only 9.5 of 1,000 diabetic men without erectile dysfunction. After a complete analysis of many other factors, the study concluded that erectile dysfunction is an early warning sign for heart disease and that it indicated a 58% increase in the risk for CHD.
Drug used for treating drug addicts can have some success in patients with inhibited sexual desire.
How is erectile dysfunction diagnosed?
Mix a pinch of turmeric with juice of embelica officinalis (Amla) and consume this in early morning.
Exercise – Aerobic exercise and weight training support the cardiovascular system, increase overall energy, and promote relaxation while at rest.
Therefore, men who produce too little cyclic GMP and men who produce too much PDE5 have problems obtaining and maintaining an erection.
GORDON F. GREEN, CDR, MC, USNR
This work has been supported by grants from the MIUR-PRIN (project no. 2005069853), Cariverona, Bando 2004 "Integrazione tra tecnologia e sviluppo di settore - Bando per progetti di ricerca a indirizzo biomedico," and the Italian Association for Cancer Research.
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That lack of clarity has led some to suggest that restless legs syndrome is an example of "disease mongering," in which drug companies expand the definitions of a disease to make it seem that more people need to be treated. Boosted by a widespread ad campaign, sales of Requip, one of the two FDA-approved treatments for restless legs syndrome, reached more than $500 million before the agency approved a generic form of the drug in 2008.
Reality: The incidence of erectile dysfunction certainly increases with age, but it is in no way an inevitable part of the aging process. Changes in erections and in the amount of time it takes to achieve one are normal signs of aging and should not be confused with ED, which is the repeated inability to get or keep an erection firm enough for sexual intercourse. Lifestyle changes, such as quitting smoking, exercising regularly, avoiding excessive alcohol consumption, and carefully monitoring chronic illnesses, like kidney disease or diabetes, can help decrease your risk of developing ED.
Supplements are intended to provide nutritional support. Because a supplement or a recommended dose may not be appropriate for all persons, a physician (i.e., a licensed naturopathic physician or holistic MD or DO) should be consulted before using any product.
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