Flagellin

From Palaeos

A fibrous protein which forms most of the shaft in the flagellae of prokaryotes. This is quite different from the 9+2 microtubular rosette which makes up the core of eukaryotic flagellae. Interesting fact: an aberrant inflammatory response to flagellin turns out to be one of, and perhaps the main causative agent in Crohn's Disease (Lodes et al., 2004).

References

Lodes, M. J., Y.-Z. Cong, C. O. Elson, R. Mohamath, C. J. Landers, S. R. Targan, M. Fort & R. M. Hershberg. 2004. Bacterial flagellin is a dominant antigen in Crohn disease. J. Clin. Invest. 113: 1296-1306.

Credits

ATW?