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(pl. flagella) A eukaryotic flagellum is a bundle of nine fused pairs of called "doublets" surrounding two central single microtubules (the so-called 9+1 structure of paired microtubules; also called the ""). At the base of a eukaryotic flagellum is a microtubule organizing center about 500 nm long, called the or kinetosome. The flagellum is encased within the cell's plasma membrane, so that the interior of the flagellum is accessible to the cell's cytoplasm. This is necessary because the flagellum's flexing is driven by the protein dynein bridging the microtubules all along its length and forcing them to slide relative to each other, and ATP must be transported to them for them to function. This extension of the cytoplasm is called the . Important note: The eukaryotic flagellum is completely different from the prokaryote flagellum in structure and in evolutionary origin. The only thing that the bacterial, archaeal, and eukaryotic flagella have in common is that they stick outside of the cell and wiggle to produce propulsion. For information on the prokaryote flagellum, see .
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Clinical tests used to diagnose ED
K Sairam and T McNicholas are the principal authors. E Kulinskaya provided statistical support. D Hanbury and G Boustead edited and revised the manuscript
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Sildenafil (Viagra), whose labeling was approved by the U.S. Food and Drug Administration (FDA) in March 1998, is the first oral medication to be marketed for the treatment of erectile dysfunction. Sildenafil inhibits the conversion of cGMP to guanosine monophosphate in the corpus cavernosum, thereby increasing the available concentration of cGMP. This reaction is largely catalyzed by the enzyme phosphodiesterase type 5. Sildenafil inhibits this enzyme, resulting in relaxation of the cavernosal smooth muscle.17 Sildenafil is absorbed rapidly, with peak plasma levels achieved within an hour. It undergoes hepatic metabolism and has a half-life of about four hours.
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HealthDay Reporter TUESDAY, May 22 (HealthDay News) -- Worried about jet lag? Researchers think they might have just the ticket to perk you up: Viagra.
One chemicals industry representative took issue with the findings. Steven Hentges, executive director of the American Chemistry Council's Polycarbonate/BPA Global Group, said the occupational exposure of these factory workers far exceeds what the average person would ingest. Furthermore, the study did not make clear if the factories or the workers were following adequate worker-protection measures, such as wearing gloves and face masks and having proper ventilation.
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An external vacuum device can be used to pull blood into the penis. A special rubber band is then used to maintain the erection during intercourse.
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Vardenafil (Levitra) can cause hypotension (abnormally low blood pressure, which can lead to fainting and even shock) when given to patients who are taking nitrates. Patients taking nitrates daily, even patients taking nitrates only once a day, should not take vardenafil. Most commonly used nitrates are medications to relieve angina (chest pain due to insufficient blood supply to heart muscle because of narrowing of the coronary arteries). These include nitroglycerine tablets, patches, ointments, sprays, pastes, and isosorbide dinitrate and isosorbide mononitrate. Other nitrates such as amyl nitrate and butyl nitrate are found in some recreational drugs called "poppers".
Substance abuse: Marijuana, heroin, cocaine, and alcohol abuse contribute to erectile dysfunction. Alcoholism, in addition to causing nerve damage, can lead to atrophy of the testicles and lower testosterone levels. For more information, please visit the Drug Abuse Center.
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Q. What are the VED disadvantages?
Severe renal impairment (CrCl <30 mL/min): Not to exceed 5 mg PO qd prn
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