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The Quaternary 11,800 years ago to now
The current epoch of time, extending from about 10,000 years BP to the present. As such, it covers the time-period when humans have had a significant effect on the world environment. The beginning of the Holocene is marked by the end of the last period, and the extinction of many of the .
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Related Health News SUNDAY, June 3 (HealthDay News) -- Gene therapy using nerve growth factors reversed erectile dysfunction in rats within four weeks, say University of Pittsburgh School of Medicine researchers.
"The novelty of this work is the new molecule we have synthesized by icariin," Dell'Agli said. "It is derived by chemical modifications of the structure of icariin, which is the active ingredient purified from E. brevicornum (horny goat weed). The mechanism by which the molecule we have found might work in humans is the inhibition of phosphodiesterase 5 (PDE 5) in the corpus cavernosum [erectile tissue in the penis], which is the mechanism by which Viagra works. This is an in vitro study. It can be considered a pre-clinical study."
Its incidence is expected to rise due to an aging population, increases in diabetes, smoking, alcohol consumption, obesity and larger numbers of patients being operated on for prostate cancer. It has been estimated that only 10 percent of men with ED visit their doctor for advice or treatment.
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Erectile dysfunction, commonly referred to as ED, is the inability to achieve and sustain an erection suitable for sexual intercourse. This condition is not considered normal at any age and is different from other problems that interfere with sexual intercourse, such as lack of sexual desire and problems with ejaculation and orgasm.
An ideal agent should be rapidly effective, easy to administer, affordable, applicable to a wide range of patients, and minimally toxic.
Other causes of male infertility may include:
Several key problems still need to be addressed. For instance, it would be of great benefit to determine the structure of several PDE holoenzymes to fully understand their mechanisms of regulation. Therefore, substantial effort is being expended in this area. A concept gaining great support is the idea that different PDEs subserve different pools of cAMP and cGMP in the cell. We are only just beginning to be able to measure PDE activity in subcellular compartments of the cell in real time. This is an area that clearly needs to be developed, including identification of molecular mechanisms that provide and control PDE subcellular localization. We also need to identify good animal models that accurately reflect the regulation and roles of PDEs in human tissues as many examples now are available for different modes of regulation between mice and men. At a minimum, putative regulatory schemes identified from studies in mouse, Drosophila, or zebrafish need to be tested quickly in human tissues.
U.S. and Japanese researchers are investigating whether firing shock-waves towards the heart will help it sprout healthy new blood vessels.
Asian ginseng— this will help increase libido and maintain an erection. The typical dosage for this herb is 1,800 mg per day.
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TUESDAY, Jan. 5 (HealthDay News) -- Men with restless leg syndrome are more likely to have erectile dysfunction, new research suggests, but it's not clear how the two conditions are related.
Professor, Department of Pharmacotherapy, College of Pharmacy, Washington State University
Due to its embarrassing nature and the shame felt by sufferers, the subject was taboo for a long time, and is the subject of many urban legends. Folk remedies have long been advocated, with some being advertised widely since the 1930s. The introduction of perhaps the first pharmacologically effective remedy for impotence, sildenafil (trade name Viagra), in the 1990s caused a wave of public attention, propelled in part by the news-worthiness of stories about it and heavy advertising.