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Homo sapiens is the species modern humans belong to. Recent populations are classified as the H. s. sapiens to distinguish from certain archaic, fossil, populations, such as H. s. idaltu. Homo sapiens first appeared around 200,000 years ago.
In Latin, homo sapiens means literally "wise human". Humans are intelligent but not necessarily wise. Human technology can change the human environment so fast that evolutionary change cannot keep up. Humans are causing problems for our descendants. Global warming is just one example. The problems are well known. We look for a solution.
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Tadalafil (Cialis) is the third oral medicine approved by the United FDA in the US for the treatment of erectile dysfunction. Like sildenafil (Viagra) and vardenafil (Levitra), tadalafil inhibits PDE5 (as described earlier).
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Gene Therapy Reverses Erectile Dysfunction in Rats
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Infertility Premature ejaculation
Healthfacts, March, 1999 by Maryann Napoli
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
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To confirm that the antitumor effect of PDE5 inhibitors was immune mediated, the experiments were repeated in immune-compromised BALB/c-Rag-2–/– mice (Fig. 1, A–C). In these hosts, sildenafil demonstrated no antitumor efficacy. Because these mice lack T and B lymphocytes but have normal or enhanced NK and NKT activity (17, 18), these results strongly suggest that the antitumor activity of PDE5 inhibition in our models is primarily caused by an adaptive immune response with either minimal NK/NKT-mediated activity, direct tumor-induced apoptosis, or tumor angiogenesis inhibition.
Figure 1. Flow diagram of patient population in the study.
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