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Erectile dysfunction (ED), also known as impotence, is the inability to achieve or sustain an erection for satisfactory sexual activity.
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Objective To assess the efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction in men with diabetes.
What medications or drugs are you currently using? This includes prescription drugs, over-the-counter drugs, herbal supplements, dietary supplements, and illegal drugs or alcohol.
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As of May 1999, postmarketing reports of sildenafil have not resulted in a change by the FDA concerning the safety of the drug. Although several patients have died after receiving prescriptions for sildenafil, it is unclear how many of these deaths resulted from appropriate use of the medication. Between late March and July 1998, 3.6 million outpatient prescriptions for sildenafil were dispensed. During the same period, 69 patients in the United States died after the confirmed use of sildenafil. No cause of death could be found in 21 of these cases. Of the remaining 48 deaths, 46 were attributed to cardiovascular events. Twelve of the men who died had taken nitroglycerin, either prescribed or self-administered. Postmarketing studies are continuing.18 A patient who has been advised not to have sex for medical reasons clearly should not be given a prescription for sildenafil.
Patient controls state of erection
Almost all antihypertensive medications have been implicated in erectile dysfunction.23 The mechanisms vary from central-acting sympatholytics, depression of libido as well as higher blood pressure requirement to achieve erection in atherosclerotic patients taking diuretics and vasodilators. The role of smoking in causing erectile dysfunction remains a source of controversy. A recent consensus group analysis failed to document a direct link to erectile dysfunction. However, smoking seems to amplify other risk factors, such as hypertension and coronary artery disease.24 Martin-Morales and colleagues25 have shown an increased risk of erectile dysfunction among smokers (odds ratio [OR] 2.5). Systemic diseases are also associated with erectile dysfunction. This is often multifactorial, as in diabetes and renal failure.26 Given the role of androgens in the physiology of erections, it is not surprising that many hypogonadal men do not experience erectile dysfunction per se. Low serum testosterone levels may be primary or secondary to another condition, such as hyperprolactinemia or hypothyroidism. Regardless of the mechanism, the result is primarily a loss of libido, although many hypogonadal men retain their ability to obtain erections.27
Hence, although it could be accurate that drunken men have better sex, intoxication isn't a solution for erectile dysfunction treatment.
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The most common side effects of sildenafil are headache, flushing and dyspepsia (Table 4).17 A small percentage of patients report an alteration in color perception. Postmarketing reports released by the manufacturer indicate infrequent occurrences of priapism. Because of the presence of phosphodiesterase in the retina, patients with retinitis pigmentosa should not be given sildenafil.
It's the 'use it or lose it' principle at work, one expert says
28.5 percent of the patients had a history of diabetes, 18.8 percent had heart disease, 37.2 percent had tried Viagra, and 7.5 percent were receiving both Uprima and nitrate therapy for angina.
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What other treatments for erectile dysfunction are being studied?
What about the pill?
Natural family planning requires a couple to learn when in the woman's cycle she can get pregnant (usually 4 days before and 2 days after ovulation). They must use a barrier method of birth control or not have intercourse during those days. There are a number of ways to keep track of a woman's ovulation. All of them require a lot of planning and commitment.
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