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Jump to: ,
   |  i. s.: Pyrosoma CGS00
   |           |--P. atlanticum CGS00
   |           `--P. spinosum MH96
   |         Octacnemus [Sorberacea] MH96
   |         Shankouclava Chen, Huang et al. 2003 CH03
   |           `--*S. anningense Chen, Huang et al. 2003 [=S. shankouense Chen, Huang et al. 2003 (n. n.)] CH03
   |--Oikopleura GD00 [Appendicularia C-S98, Larvacea]
   |    |--O. dioica LG03
   |    |--O. labradoriensis B26
   |    `--O. vanhoeffeni B26
   `--Tunicata C-S98
        |--Thaliacea [Thaliae] C-S98
        |    |--Thalia democratica BN03
        |    `--Doliolum W01
        |         |--D. mulleri Krohn 1852 W01
        |         `--D. nationalis CGS00
        `--Ascidiacea [Ascidiae] C-S98
             |  i. s.: Halocynthia RZ03
             |           |--H. aurantiaca RZ03
             |           `--H. roretzi CGS00
             |         Polysyncraton RZ03
             |         Clarelina molucensis RZ03
             |         Phallusia CGS00
             |           |--P. mamillata CGS00
             |           `--P. nigra B79
             |         Polyandrocarpa B79
             |           |--P. gravei B79
             |           `--P. tincta B79
             |         Symplegma viride B79
             |         Diplosoma listerianum B79
             |         Ctenicella appendiculata M62
             |         Distomus variolosus M62
             |         Herdmania curvata CGS00
             |         Asterocarpa coerulea HS01
             |         Cnemidocarpa bicornuata HS01
             |-- S79
             `-- S79

* Type species of generic name indicated

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[B26] Bigelow, H. B. 1926. Plankton of the offshore waters of the Gulf of Maine. Bulletin of the Bureau of Fisheries 40 (2): 1-509.

[BN03] Bourlat, S. J., C. Nielsen, A. E. Lockyer, D. T. J. Littlewood & M. J. Telford. 2003. Xenoturbella is a deuterostome that eats molluscs. Nature 424: 925-928.

[B79] Buss, L. W. 1979. Habitat selection, directional growth and spatial refuges: Why colonial animals have more hiding places. In Biology and Systematics of Colonial Organisms (G. Larwood & B. R. Rosen, eds.) pp. 459-497. Academic Press: London.

[CGS00] Cameron, C. B., J. R. Garey & B. J. Swalla. 2000. Evolution of the chordate body plan: New insights from phylogenetic analyses of deuterostome phyla. Proceedings of the National Academy of Sciences of the USA 97 (9): 4469-4474.

[C-S98] Cavalier-Smith, T. 1998. A revised six-kingdom system of life. Biological Reviews 73: 203-266.

[CH03] Chen, J.-Y., D.-Y. Huang, Q.-Q. Peng, H.-M. Chi, Z.-Q. Wang & M. Feng. 2003. The first tunicate from the Early Cambrian of South China. Proceedings of the National Academy of Sciences of the USA 100 (14): 8314-8318.

[GD00] Giribet, G., D. L. Distel, M. Polz, W. Sterrer & W. C. Wheeler. 2000. Triploblastic relationships with emphasis on the acoelomates and the position of Gnathostomulida, Cycliophora, Plathelminthes, and Chaetognatha: A combined approach of 18S rDNA sequences and morphology. Systematic Biology 49: 539-562.

[LG03] Lancelot, C., & R. Groben. 2003. Meeting report: Regional conference on the ecology and impact assessment of Phaeocystis blooms in the Eastern Channel and Southern Bight of the North Sea. Protist 154 (2): 173-176.

[MH96] Miller, S. A., & J. P. Harley. 1996. Zoology (3rd ed.) Wm. C. Brown Publishers: Dubuque (Iowa).

[M62] Monniot, F. 1962. Recherches sur les graviers a Amphioxus de la région de Banyuls-sur-Mer. Vie et Milieu 13: 231-322.

[RZ03] Romanenko, L. A., N. V. Zhukova, M. Rhode, A. M. Lysenko, V. M. Mikhailov & E. Stackebrandt. 2003. Pseudoalteromonas agarivorans sp. nov., a novel marine agarolytic bacterium. International Journal of Systematic and Evolutionary Microbiology 53: 125-131.

[S79] Sabbadin, A. 1979. Colonial structure and genetic patterns in ascidians. In Biology and Systematics of Colonial Organisms (G. Larwood & B. R. Rosen, eds.) pp. 433-444. Academic Press: London.

[W01] Williamson, D. I. 2001. Larval transfer and the origins of larvae. Zoological Journal of the Linnean Society 131: 111-122.


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Testicular cancer affects one of every 2,000 men with undescended testicles. This rate of testicular cancer is higher than the rate in men whose testicles have dropped naturally. When the testicle is inside the scrotum, a man can easily feel his testicles to check for a tumor, or he can be checked by his doctor. This way, any tumor can be found early, when the cancer is easier to cure. Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients Bulbocavernosus reflex: This test evaluates nerve sensation in the penis. During the test, your doctor will squeeze the head of your penis, which should immediately cause your rectum to contract. If nerve function is abnormal, there will be a delay in response time or absence of rectal contraction. cGMP was measured on purified CD11b+, CD11c+, CD4+, or CD8+ cells using the Cyclic GMP EIA kit (Cayman Chemical). Data analysis was performed with the workbooks available at http://www.caymanchem.com/neptune/servlet/neptune/template/analysis%2CEIA.vm/a/z. Data are expressed as mean ± SE of quadruplicate wells. Besides diabetes, which is very common in the U.S. today, there are other, somewhat rarer things that affect the nervous system and can in turn cause erectile dysfunction. Homeopathy Phosphodiesterase-5 (PDE5) inhibitors (sildenafil, tadalafil, and vardenafil) are agents currently in clinical use for nonmalignant conditions. We report the use of PDE5 inhibitors as modulators of the antitumor immune response. In several mouse tumor models, PDE5 inhibition reverses tumor-induced immunosuppressive mechanisms and enables a measurable antitumor immune response to be generated that substantially delays tumor progression. In particular, sildenafil, down-regulates arginase 1 and nitric oxide synthase–2 expression, thereby reducing the suppressive machinery of CD11b+/Gr-1+ myeloid-derived suppressor cells (MDSCs) recruited by growing tumors. By removing these tumor escape mechanisms, sildenafil enhances intratumoral T cell infiltration and activation, reduces tumor outgrowth, and improves the antitumor efficacy of adoptive T cell therapy. Sildenafil also restores in vitro T cell proliferation of peripheral blood mononuclear cells from multiple myeloma and head and neck cancer patients. In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy. To determine whether the immunomodulatory effect of PDE5 inhibition affected T cell activation within the tumor microenvironment, we examined IL-2 production by TILs using a transgenic mouse in which expression of GFP is under an IL-2 promoter (BALB/c–IL-2p/GFP) (25). In this model, T cell stimulation activates the IL-2 promoter and results in expression of the reporter transgene, GFP, which is easily detectable by flow cytometry. C26GM-primed BALB/c–IL-2p/GFP splenocytes were adoptively transferred into tumor-bearing recipients that were either left untreated or treated with sildenafil for 9 d. Single cell suspensions of the tumor-infiltrating CD8+ T cells were analyzed by flow cytometry for GFP expression. Adoptively transferred, vaccine-primed T cells were activated in the tumor microenvironment only in the presence of PDE5 inhibition, whereas in its absence they produced no IL-2 and, hence, were bona fide anergic T cells (Fig. 4 D). To further prove that these effects were dependent on CD8+ T cells, mice were challenged with C26GM and were (a) left untreated, (b) given sildenafil, (c) given an anti-CD8+ depleting antibody, or (d) given both sildenafil and the CD8+ depleting antibody. Sildenafil treatment again demonstrated a statistically significant reduction in tumor outgrowth, an effect completely abrogated by CD8+ depletion (Fig. 4 E). These experiments demonstrate that PDE5 inhibition enhances the tumor-specific T cell response, increases intratumoral T cell infiltration and activation, and underscores the role of CD8+ T cells in sildenafil-mediated antitumor responses. Viagra® undoubtedly represents a very significant advance in the treatment of erectile dysfunction, but like most drugs it is not without its cautions, contraindications and potential side effects, etc. Pharmacy One simple device now making a comeback is the penile pump. It's a vacuum pump that lets a man draw blood into the penis. A constriction ring placed at the base of the penis keeps the penis erect during intercourse. How is ED diagnosed? The patch's side effects are similar to those of the pill. Women who use the patch should not smoke.

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