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Many men achieve stronger erections by injecting drugs into the penis, causing it to become engorged with blood. Drugs such as papaverine hydrochloride, phentolamine, and alprostadil (marketed as Caverject) widen blood vessels. These drugs may create unwanted side effects, however, including persistent erection (known as priapism) and scarring. Nitroglycerin, a muscle relaxant, can sometimes enhance erection when rubbed on the penis. Alprostadil (Caverject Injection, Edex Injection, MUSE Pellet) Erectile dysfunction affects, to some degree, 52 percent of men aged 40 to 70 years in the United States and 322 million men worldwide. The condition is linked with age, risk factors for atherosclerosis (hardening of the arteries) and heart disease, according to background information for the study. The paper was expected to be published Wednesday in the online edition of the European Heart Journal. View All men at one time or another will experience ED. Only if the problem becomes persistent -- occurs more than 50% of the time, or becomes a source of distress for you or your partner should you be concerned and consider seeking medical advice and treatment. For men whose erectile dysfunction is caused by psychological problems, therapy may be needed. Depression that accompanies ED is treatable. The first step in overcoming depression is to be honest with yourself, your partner, and your doctor. After depression has been brought out into the open, coping with it will be easier and less stressful. Sildenafil is available in 3 doses: 25 mg, 50 mg, and 100 mg. The starting dose depends on the clinical situation. A man in his fifth decade of life with mild sexual dysfunction that is probably related to psychological factors can start on the 25-mg dose. Men with moderate-to-severe ED can begin at the 50-mg dose, and, after testing the effect of the drug on at least 3 occasions (although 5-6 tries is recommended), the dose can be modified. Men with severe ED can start on the 100-mg dose; these men are not likely to achieve a satisfactory response, but they should make 3-4 attempts before starting another form of therapy. Advertising Disclaimer Of the men surveyed, 395 reported having restless legs at least 15 times a month. They were more likely than the other men to use antidepressants and more likely to smoke. Alcohol and tobacco use Erectile Dysfunction Affects 18 Million U.S. Men Strengthen the heart. Their study involved 1126 men, between 50 and 70 years of age, without erectile dysfunction in 1994 when they completed a questionnaire that included, among other things, questions about erectile function and medication usage. The questionnaire was then re-administered five years later. Professor, Department of Pharmacotherapy, College of Pharmacy, Washington State University It triggers the release of an important substance called Vascular Endothelial Growth Factor, or VEGF, which sends out a signal for new blood vessels to start growing. As erectile dysfunction causes begin to move over into awareness, a man can lose his energy and self esteem that results in poor job performance and the distancing of friends and family. A patient also might decide that it's just not worth getting treated, particularly if the tumor is slow-growing. Dependable erections are not necessarily a sure sign of excellent health, but a penis that won't rise to the occasion is a warning that something may be awry. For any medication to be effective, the physiologic components involved in the erectile process must be functional. Serious impairments render the medication either completely or partially ineffective. The use of oral therapy has long been preferred over invasive procedures such as injection therapy for erectile dysfunction. We review the pharmacology, efficacy and side effects of the newest agents available for oral therapy: the PDE-5 inhibitors sildenafil, vardenafil and tadalafil.

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