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| rowspan="4" colspan="2" style="{{Color-Silurian}}" | [[Silurian]]
| rowspan="4" colspan="2" style="{{Color-Silurian}}" | [[Silurian]]
| style="{{Color-Pridoli}}" | [[Pridoli]]
| style="{{Color-Pridoli}}" | [[Pridoli]]
| rowspan="4" style="background-color:white" | First [[Vascular tissue|vascular]] [[Plantae|plant]]s (the [[whisk fern]]s and their relatives), first [[millipede]]s and [[Arthropleurida|arthropleurid]]s on land. First jawed [[fish]]es, as well as many [[ostracoderm|armoured]] [[agnatha|jawless]] fish, populate the seas. [[Eurypterid|Sea-scorpions]] reach large size. [[Tabulate coral|Tabulate]] and [[Rugosa|rugose]] corals, [[brachiopod]]s ([[Pentamerida]], [[Rhynchonellida]], etc.), and [[crinoid]]s all abundant. [[Trilobite]]s and [[mollusk]]s diverse; [[graptolite]]s not as varied.
| rowspan="4" style="background-color:white" | First [[vascular plant]]s (the [[whisk fern]]s and their relatives), first [[millipede]]s and [[Arthropleurida|arthropleurid]]s on land. First jawed [[fish]]es, as well as many [[ostracoderm|armoured]] [[agnatha|jawless]] fish, populate the seas. [[Eurypterid|Sea-scorpions]] reach large size. [[Tabulate coral|Tabulate]] and [[Rugosa|rugose]] corals, [[brachiopod]]s ([[Pentamerida]], [[Rhynchonellida]], etc.), and [[crinoid]]s all abundant. [[Trilobite]]s and [[mollusk]]s diverse; [[graptolite]]s not as varied.
| style="{{Color-Pridoli}}" | 418.7 ± 2.7 <sup>*</sup>
| style="{{Color-Pridoli}}" | 418.7 ± 2.7 <sup>*</sup>

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<--- More on time and timescales, and a submenu, to be added -->

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Time is change and evolution. Time ties together the world we experience. Without time we would only experience objects and ideas randomly without any sort of connection or distinction. Time allows use to understand that everything has an influence beyond the original cause that created it.

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Most of the information on the following page is copied - The divisions in this table are not to scale.

1 Major Events Start, Million
Years Ago2
3 End of and rise of agriculture (c.10000 BCE) and (c.3500 BCE) in the Fertile Crescent. 0.011430 ± 0.000139
Flourishing and then extinction of many large (). Evolution of anatomically modern . 1.806 ± 0.005 *
Intensification of present ; cool and dry . , many of the existing genera of mammals, and recent appear. appears during the end of this period (c.2.5 Mya). 5.332 ± 0.005 *
Moderate climate; in . Modern and families became recognizable. and diverse. become ubiquitous. First appear. The common ancestor of Humans and Chimpanzees lived during this period. 23.03 ± 0.05 *

Warm climate; Rapid and diversification of fauna, especially . Major evolution and dispersal of modern types of 33.9±0.1 *
Archaic (e.g. , , , etc) flourish and continue to develop during the epoch. Appearance of several "modern" mammal families. Primitive diversify. First . Reglaciation of ; current ice age begins. 55.8±0.2 *
Climate tropical. Modern appear; diversify into a number of primitive lineages following the . First large mammals (up to bear or small hippo size). 65.5±0.3 *
proliferate, along with new types of insects. More modern fish begin to appear. , , , and all common. Many new types of (e.g. , , , and ) evolve on land, as do ; and and modern sharks appear in the sea. Primitive gradually replace pterosaurs. , and mammals appear. Break up of . Possible appearance of first . 99.6±0.9 *
145.5 ± 4.0
Gymnosperms (especially , and ) and common. Many types of , such as , , and . Mammals common but small. First and . and diverse. , and abundant. very common, along with , starfish, , and and . Breakup of into and . 161.2 ± 4.0
175.6 ± 2.0 *
199.6 ± 0.6
dominant on land as , in the oceans as and , and in the air as . become smaller and more mammal-like, while first and appear. flora common on land. Many large aquatic amphibians. extremely common. and fish appear, as do many modern clades. 228.0 ± 2.0
245.0 ± 1.5
251.0 ± 0.4 *
Landmasses unite into supercontinent , creating the . End of Permo-Carboniferous glaciation. ( and ) become plentiful, while and remain common. In the mid-Permian, -age flora are replaced by -bearing (the first true ) and by the first true . and evolve. Marine life flourishes in warm shallow reefs; and brachiopods, , , and all abundant. occurs 251 mya: 95 percent of life on Earth becomes extinct, including all , , and . 260.4 ± 0.7 *
270.6 ± 0.7 *
299.0 ± 0.8 *
4 /
radiate suddenly; some (esp. and ) are quite large. common and diverse. First and forests (, ferns, , , , etc.). Highest-ever levels. , brachiopods, bryozoa, bivalves, and corals plentiful in the seas. Testate proliferate. 306.5 ± 1.0
311.7 ± 1.1
318.1 ± 1.3 *
Large , first , and amphibious live amid -forming coastal . Lobe-finned are big fresh-water predators. In the oceans, early are common and quite diverse; (esp. and ) abundant. , , and brachiopods (, , etc.) very common. But and decline. in East . 326.4 ± 1.6
345.3 ± 2.1
359.2 ± 2.5 *
First , and appear, as do the first -bearing plants (), first (the tree-fern ), and first (wingless) . and , and corals, and are all abundant in the oceans. are plentiful, while squid-like arise. and decline, while jawed fishes (, and fish, and early ) rule the seas. First still aquatic. "Old Red Continent" of . 385.3 ± 2.6 *
397.5 ± 2.7 *
416.0 ± 2.8 *
First (the and their relatives), first and on land. First jawed , as well as many fish, populate the seas. reach large size. and corals, (, , etc.), and all abundant. and diverse; not as varied. 418.7 ± 2.7 *
Upper/Late () 422.9 ± 2.5 *
428.2 ± 2.3 *
Lower/Early () 443.7 ± 1.5 *
diversify into many new types (e.g., long ). Early , articulate (Orthida, Strophomenida, etc.), , , , , , many types of (, , , etc.), branched , and other taxa all common. (early ) appear. First and on land. Ice age at end of period. First appear (c.450–420 MYA). 460.9 ± 1.6 *
471.8 ± 1.6
488.3 ± 1.7 *
Upper/Late () Major diversification of life in the . Many fossils; most modern appear. First appear, along with a number of extinct, problematic phyla. Reef-building abundant; then vanish. , worms, , inarticulate (unhinged lampshells), and many other animals numerous. are giant predators, while many Ediacaran fauna die out. , (e.g., ), and continue to present day. emerges. 501.0 ± 2.0 *
513.0 ± 2.0
542.0 ± 0.3 *

Good of . Ediacaran fauna (or ) flourish worldwide in seas. of worm-like Trichophycus, etc. First and . Enigmatic forms include oval-shaped , frond-shaped , and many soft-jellied creatures. 630

+5/-30 *

Possible "" period. still rare. landmass begins to break up. 850 n.6
supercontinent persists. of simple . First radiation of -like . 1000
Narrow highly belts due to as supercontinent is formed. 1200
continue to expand. colonies in the seas. 1400
expand. 1600
First : with nuclei. is the primoidal supercontinent. 1800
The became . and asteroid impacts. Much . 2050
occurs. glaciation occurs possibly as a result of the increase of free oxygen and the decrease of CO2 and methane in the atmosphere. 2300
: result. Many clades of anaerobic CO2 dependent microorganisms may have died in a mass extinction that resulted from the oxygen catastrophe. 2500

Stabilization of most modern ; possible event. 2800
First (probably colonial ). Oldest . 3200
First known . Oldest definitive . Earliest continent forms (c 3600 or 3300 Mya). 3600
(probably and perhaps ). Oldest probable . 3800

5, 7
8   c.3850
8 Oldest known (4100 mya). c.4150
Formation of the (4570 ). Oldest known (4400 mya). Formation of first possible oceans (c 4400 Mya). Collision of the planet and the creates the . c.4570

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note 1. Paleontologists often refer to rather than geologic (geological) periods. The stage nomenclature is quite complex. See for an excellent time ordered list of faunal stages.

note 2. Dates are slightly uncertain with differences of a few percent between various sources being common. This is largely due to uncertainties in and the problem that deposits suitable for radiometric dating seldom occur exactly at the places in the geologic column where they would be most useful. The dates and errors quoted above are according to the 2004 time scale. Dates labeled with a * indicate boundaries where a has been internationally agreed upon: see for a complete list.

note 3. Historically, the has been divided up into the and sub-eras, as well as the and periods. In recent years, the first decided to stop endorsing the terms Quaternary and Tertiary as part of the formal nomenclature, then to switch to a three-period scheme consisting of Paleogene, Neogene, and Quaternary, as shown. This probably ensures that everyone is equally unhappy.

note 4. In North America, the Carboniferous is subdivided into and Periods.

note 5. The , and are often collectively referred to as the or Cryptozoic.

note 6. Defined by absolute age ().

note 7. Though commonly used, the is not a formal eon and no lower bound for the Archean has been agreed upon. The Hadean has also sometimes been called the Priscoan or the Azoic.

note 8. These era names were taken from the . Their use for Earth geology is unofficial.

note 9. The start time for the epoch is here given as 11,430 ± 130 years (that is, between 9610 B.C. and 9350 B.C.). For further discussion of the dating of this epoch, see .


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Male infertility is also quite different from impotence. A man who is unable to maintain an erection may be very capable of producing sperm that could fertilize an egg. An infertile man is usually able to maintain an erection, but he may be unable to father a child due to problems with sperm count or other factors. Therefore, men with these conditions should not use vardenafil without having these conditions evaluated and stabilized first. For example, men with uncontrolled high blood pressure should have their blood pressure controlled; and men with potentially life-threatening abnormal heart rhythms should have these rhythms controlled. Pulmonary hypertension -- the incurable condition of continuous high blood pressure in the pulmonary artery located in the right ventricle of the heart -- is one of many serious complications that can strike COPD patients. PAH causes the artery, which is responsible for delivering blood from the heart to the lungs, to work harder than normal. A weakening of the heart muscle can ensue over time, increasing the risk of heart failure and even death. We next sought to determine whether we could restore T cell proliferation of PBMCs isolated from head and neck and MM patients stimulated with anti-CD3/CD28 antibody-coated beads in the presence or absence of sildenafil. The expansion of CD4+ and CD8+ T cells obtained from MM or head and neck patients was significantly less than that observed using healthy donors (Fig. 8 B). In contrast, in the presence of sildenafil, PBMCs from MM and head and neck patients expanded similarly to sildenafil-treated PBMCs from healthy donors (Fig.8 B). Interestingly, qualitative differences in T cell expansion emerged between the two malignancies. In head and neck patients, CD8+ T cell proliferation is restored with PDE5 inhibition while CD4+ lymphocyte expansion in the same condition is only partially augmented. In contrast, CD4+ T cell proliferation is restored and minimal effects are seen on CD8+ lymphocyte expansion with PDE5 blockade in myeloma (Fig. 8 B). "It has a long way to go, but the researchers have basically shown they can take cells from an organ, culture them, put them back in and have them be functional," McCullough said. "This is especially impressive because the penis is an organ that's a very sensitive hydraulic pump, so to speak. During an erection, blood has to flow into the organ. The organ then has to expand and then shut down the drainage so the blood doesn't flow back out. And all of these things are very interrelated." The researchers, led by Constance Bacon, a former post-doctoral fellow at HSPH, and Eric Rimm , associate professor of epidemiology and nutrition at HSPH, surveyed 22,086 healthy subjects between the ages of 40 and 75 from the Health Professionals Follow-up Study who reported good or very good erectile function and no major chronic disease before 1986. Among the participants, 17.7 percent (3,905) reported new onset of ED between 1986 and 2000. The researchers adjusted the results to take into account those with and without prostate cancer during the follow-up period, since prostate cancer treatments, such as radiation or surgery, may lead to ED. Men with a rare heart condition known as long QT syndrome should not take vardenafil since this may lead to abnormal heart rhythms. The QT interval is the time it takes for the heart's muscle to recover after it has contracted. The QT interval is measured with an electrocardiogram (EKG). Some patients have longer than normal QT intervals, and they may develop potentially life-threatening abnormal heart rhythms, especially when given certain medications. Since long QT syndrome can be inherited, men with a family history of long QT syndrome should not take vardenafil. Furthermore, vardenafil is not recommended for men who are taking medications that can affect the QT interval such as quinidine (Quinaglute, Quinidex), procainamide (Pronestyl; Procan-SR; Procanbid), amiodarone (Cordarone), and sotalol (Betapace). According to ayurvedic text ashtanga sangraha, diabetes is caused due to vitiation of vata. pitta, kapha and rakta (blood). Vitiated doshas affect almost all tissues of body in diabetes. According to ayurveda the process of erection occurs due to involvement of vata, pitta and rakta . The process of erection will be normal when vata, pitta and rakta are in normal and balanced condition.Vitiated vata fails to cause normal flow of signals and arousal does not occur. Vitiated pitta and rakta fail to complete the process of blood flow to penis. Less active in inhibiting PDE-6, resulting in fewer visual disturbances; less than 0.1% of men reported this symptom Effects of Impotence FRIDAY, Oct. 3 (HealthDay News) -- A Chinese herbal remedy known as "horny goat weed" may indeed live up to its name as a natural version of Viagra. There are many natural ways to deal with erectile dysfunction like the very first step is to take exercises daily. Exercises help you to boost energy as well as the low level of testosterone. Exercises improve the flow of blood to the male sexual organ and over all health. Second step is to start taking vitamins which can help you to deal with erectile dysfunction. Here is the list of vitamins that cures the erectile dysfunction. Their study involved 1126 men, between 50 and 70 years of age, without erectile dysfunction in 1994 when they completed a questionnaire that included, among other things, questions about erectile function and medication usage. The questionnaire was then re-administered five years later. And finally, have fun trying new and different techniques, positions, accessories, etc. There is hope for ED, and you can have a fulfilling and satisfactory sex life. Dont put too much pressure on yourself. Enjoy! A useful and simple way to distinguish between physiological and psychological impotence is to determine whether the patient ever has an erection. If never, the problem is likely to be physiological; if sometimes (however rarely), it is more likely to be psychological. The doctor says you have erectile dysfunction (ED). It sounds terrible, but it's not the end of your sex life. In fact, your sex life probably is about to get much better. Viagra Onlinee Homeopathy is an extremely individualized system of treatment. The homeopath will want to know information about the patients constitution, lifestyle, medical history, and current symptoms in order to suggest the correct remedies.

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